The unique and replaceable polyethylene (PE) Safe-Cone Filters act as a final barrier to prevent any fluids and liquid vapours from reaching the internal components of the pipette. Standard Safe-Cone Filters are for general applications. They can be used for the same type of work as the Plus Filter is recommended for, but need to be changed more frequently.

Self-sealing Plus Safe-Cone Filters are meant for applications such as radioactive work, cell culture, bacterial and virological work and molecular biology. The interval of changing the filter depends on the application and the sample. However, according to studies, the filter should be changed daily (or after 50 to 250 pipettings) and immediately in case of over-aspiration. To ensure safety of the user, forceps should be used to change the filter. The mLINE® pipettes also feature a built-in filter ejector. In addition, clean the tip cone with ethanol (70%) prior to assembling a new filter.