Guanidine Thiocyanate (Guanidinium thiocyanate or guanidinium isothiocyanate), a powerful protein denaturant, is most often used to inactivate endogenous RNases in the isolation of RNA from various tissues and bacteria. When used with acid-equilibrated phenol or phenol:chloroform, a solution of Guanidine Thiocyanate and beta-mercaptoethanol are very effective in disrupting both cytoplasmic and nuclear membranes while maintaining the integrity of the RNA.

Apex brand products are produced in manufacturing facilities that feature state-of-theart automation and are certified to ISO 2001:2008. Automated buffer production and filling facilities are designed to produce bulk chemicals as well as smaller custom batches. At Apex, we understand that our products can be used in regulated environments and therefore must meet exacting quality standards. Our manufacturing facilities have a quality system that is designed for cGMP compliance and ensures that all products are made to required specifications.